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Institute of Science Tokyo was formed on 1 October 2024 by merging Tokyo Institute of Technology, which traces its roots to the Tokyo Vocational School of 1881, with Tokyo Medical and Dental University, founded as a dental school in 1928. The merger was agreed in 2022 and enacted through a 2023 amendment to Japan's national university law. Its headquarters are on the former Tokyo Tech campus at Ookayama, Meguro.